Musk ketone
Musk ketone
CAS: 81-14-1
Molecular Formula: C16H30O
Musk ketone - Names and Identifiers
Musk ketone - Physico-chemical Properties
| Molecular Formula | C16H30O |
| Molar Mass | 238.41 |
| Density | 1.2051 (rough estimate) |
| Melting Point | 134-137 °C |
| Boling Point | 436.08°C (rough estimate) |
| Flash Point | 2 °C |
| Water Solubility | Insoluble (<0.1 g/100 mL at 20 ºC) |
| Solubility | Insoluble in water, glycol, glycerin, insoluble in ethanol, soluble in benzyl benzoate, animal oil and essential oil. |
| Appearance | Colorless oily liquid |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.511 |
| MDL | MFCD00211114 |
| Physical and Chemical Properties | Pale yellow powder or flake crystal. Melting point of 134.5-136.5 ℃, soluble in 95% ethanol 1.8%, benzyl benzoate 25%, benzyl alcohol 13% and other oil flavor, flash point> 100 ℃. There are sweet and musk-like animal fragrance, aroma is soft, quite lasting. |
| Use | The use is important for one of the best Nitro Musk and is a good fixative. Widely used in flavor formula, where the need for Musk aroma are available, especially in the sweet, Oriental and heavy flavor flavor. With methyl ionone, cinnamyl alcohol, benzyl salicylate and other co-can produce powder flavor. Can be used in the appropriate amount of soap flavor, the dosage is generally 1%-5%. |
Musk ketone - Risk and Safety
| Risk Codes | R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste. S46 - If swallowed, seek medical advice immediately and show this container or label. |
| UN IDs | UN1648 3/PG 2 |
Musk ketone - Reference
| Reference Show more | 1. Tong Jun, Wang Junjun, Chen Yong. Effects of muscone on pharmacokinetics and brain distribution of curcumin in rats [J]. Journal of Hubei University (Natural Science Edition), 2018, 40(06):64-69. 2. [IF = 5.64] Wu Dousheng et al."Oleanolic acids the Type III secret System of Ralstonia solanacearum." Front Microbiol. 2015 Dec;0:1466 3. [IF=4.225] Zhai Xiao et al."Muscone Ameliorates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κb Ligand-Induced Osteoclastogenesis by Suppressing TNF Receptor-Associated Factor 6-Mediated Signaling Pathways."Front Pharmacol. 2020 Mar;0:348 |
Musk ketone - Determination of keto musk in cosmetics by reversed-phase high performance liquid chromatography
From HowNet
Author:
Chen Zhirong ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(6 d27a66ca98f9078) author:(Gao Xiao ) "target = "_blank"> Gao Xiao ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(bab5508fbd44358e) author:(Mu Min)" target = "_blank"> Mu/a >,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(59 eba4485aeb17a6) author:(Zhang pengxiang)" target = "_blank"> Zhang pengxiang ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(18 f99ceb9b6e046c) author:(Zhao Hua)" target = "_blank"> Zhao Hua
Summary:
Keto musk is a restricted substance in cosmetics and has carcinogenic effect on human body. Therefore, it is necessary to analyze its content. Ultrasonic-assisted extraction was used to pretreat cosmetic samples of different matrix types. Determination of keto musk in cosmetics by reversed-phase high performance liquid chromatography. The chromatographic conditions are as follows: Kromasil C18(250mm × 4.6mm I. d.,5 μm) column, mobile phase V (acetonitrile): V (water) = 80: 20, flow rate 1.0 mL/min, detection wavelength 235nm. The results showed that under these conditions, keto musk had a good linear relationship with the corresponding peak area in the range of 0.5-150 μg/mL (correlation coefficient r was 0.9998), and the linear regression equation was A = 13500 & rho;-4829, recovery rate 90.5%-102.5%,RSD 0.45%-0.98%. Therefore, the established method for the determination of keto musk in cosmetics by reversed-phase high performance liquid chromatography is accurate, reliable, and has wide applicability, which can provide a certain reference for the analysis of keto musk and the formulation of relevant national regulations.
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keywords:
cosmetics; High performance liquid chromatography; Ultrasonic-assisted extraction; Ketono musk
DOI:
10.3981/j.issn.1000-7857.2011.21.006
cited:
Year:
2011
Last Update：2024-01-02 23:10:35
Musk ketone - A method for the synthesis of ketone musk by-product tert-butanol-water azeotrope of propyl lactone
from Baidu library
patent type:
patent for invention
application (patent) number:
CN202011564330.5
date of application:
20201225
public/announcement number:
CN112661652A
date of publication/announcement:
20210416
Applicant (patentee):
anhui huaye spice co., ltd
Inventor:
Wang Tianyi ,< a href = "https://xueshu.baidu.com/s?wd=author: (Fan Yiyi) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Fan Yiyi ,< a href = "https://xueshu.baidu.com/s?wd=author: (Wang yang) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Wang yang , Zhang Zheng , Wu Xu ,< a href = "https://xueshu.baidu.com/s?wd=author: (He Yunfei) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> He Yunfei
national and provincial code:
CN340824
Summary:
The present invention discloses a method for synthesizing ketomusk from the by-product tert-butanol water azeotrope of propyl lactone. The by-product tert-butanol in the production process of propyl lactone is used as the starting material, and hydrochloric acid is chlorinated to obtain chloro-tert-butane; in the presence of aluminum trichloride, chloro-tert-butane under, under the catalysis of aluminum trichloride, 1,3 dimethyl 5 tert-butylbenzene and acetyl chloride undergo acylation reaction to obtain 2,6 dimethyl 4 tert-butylacetophenone; with sulfuric acid as the catalyst, 2,6 dimethyl 4 tert-butylacetophenone and nitric acid are nitrated to obtain crude ketone musk, which is purified by a series of separation and purification such as neutralization, crystallization
Last Update：2023-08-16 22:23:51
Musk ketone - Introduction
Pharmacological effects: It has the role of barren central nervous system, respiratory center and heart in pharmacology, and promotes the secretion of various ureas in drought. It is an important drug for the treatment of confusion. It can protect coronary arteries, increase coronary flow, and play a role in promoting blood circulation, detumescence, and pain relief. In addition, there is the role of exciting the uterus and enhancing the contraction of uterine smooth muscle, so pregnant women should not use it. Musk is famous for clearing all orifices, opening meridians, penetrating muscles and bones, internal treatment of stroke, middle qi, middle evil and infantile convulsions, and external treatment of iron injury and sores.
Last Update：2022-10-16 17:30:40
Musk ketone - Carbon fiber decolorization device for ketone musk
from Baidu library
patent type:
Utility Model
application (patent) number:
CN201921588452.0
date of application:
20190924
public/announcement number:
CN210711461U
date of publication/announcement:
20200609
Applicant (patentee):
Puyang Eurasia Chemical Technology Co., Ltd.
Inventor:
Zhao Honglei ,< a href = "https://xueshu.baidu.com/s?wd=author: (Liu Guopeng) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Liu Guopeng ,< a href = "https://xueshu.baidu.com/s?wd=author: (Chen Yunsheng) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Chen Yunsheng
national and provincial code:
CN410926
Summary:
This utility model belongs to the technical field of ketone musk decolorization, in particular to a ketone musk using carbon fiber decolorization device. Aiming at the problems that the existing ketone musk decolorization device is inconvenient to use, low decolorization efficiency, and cannot meet the use requirements, the following is proposed The solution includes a base, a decolorization box is arranged on the top of the base, a sealing cover is movable connected, the outer side of the twill tube is provided with twill, the top of the sealing cover is rotatably installed with a longitudinal rod, the top of the longitudinal rod is fixedly installed with a helical gear, the helical gear meshes with the twill, the fixing sleeve in the twill tube is equipped with a round rod, the outer side of the round rod is fixedly installed with a multiple support frame, the support frame is rotatably installed with a connecting shaft, the outer side, high decolorization efficiency, easy to clean
Last Update：2023-08-16 22:23:51
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Tel: +86 0571-86722205
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Product Name: Musk ketone Request for quotation
CAS: 81-14-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
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CAS: 81-14-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
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Tel: 18301782025
Email: 3008007409@qq.com
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